| DRUG WATCH |
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| Year : 2011 | Volume
: 43
| Issue : 5 | Page : 603-604 |
Diuretics induced uremia and nonrecovery of renal function in a patient with acute renal failure caused by sepsis
PK Sahu1, A Pal1, J Panda2, S Patnaik1
1 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa, India
2 Department of Pharmacology,Hi tech College of Pharmacy, Bhubaneswar, Orissa, India
Correspondence Address:
P K Sahu
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.84983
Sepsis is a clinical syndrome related to severe infection and is characterized by systemic inflammation and injury to multiple organs and functional systems. Sepsis is one of the main causes of acute renal failure (ARF). Diuretics are frequently administered during ARF. However, there is scant evidence that diuretics provide any benefit to the patients with ARF. This case report highlights the occurrence of uremia and nonrecovery of renal function after administration of diuretics in a patient with ARF caused by sepsis. It is suggested that physicians should be cautious in prescribing diuretics to patients with ARF due to septicemia. Diuretics cause uremia and may lead to false diagnosis of chronic renal failure and nonrecovery of renal function. The patient may unnecessarily require prolonged dialysis.
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