IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 22557 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded216    
    Comments [Add]    
    Cited by others 16    

Recommend this journal


Year : 2011  |  Volume : 43  |  Issue : 3  |  Page : 340-344

Studies on the activity of Cyperus rotundus Linn. tubers against infectious diarrhea

1 The Foundation for Medical Research, Worli, Mumbai, India
2 Naoroji Godrej Centre for Plant Research, Lawkin Ltd. Campus, Shirwal, Satara, India

Correspondence Address:
Tannaz J Birdi
The Foundation for Medical Research, Worli, Mumbai
Login to access the Email id

Source of Support: Grant No. 91283, Department of Science and Technology, Ministry of Science and Technology, Government of India, Conflict of Interest: None

DOI: 10.4103/0253-7613.81502

Rights and Permissions

To study the antidiarrheal activity of the decoction of Cyperus rotundus Linn. tubers using representative assays of diarrheal pathogenesis and understand its mechanism of action.Antibacterial, antigiardial and antirotaviral activities were studied. Effect on adherence of enteropathogenic Escherichia coli (EPEC) and invasion of enteroinvasive E. coli (EIEC) and Shigella flexneri to HEp-2 cells was evaluated as a measure of effect on colonization. Effect on enterotoxins such as enterotoxigenic E. coli (ETEC) heat labile toxin (LT), heat stable toxin (ST) and cholera toxin (CT) was also assessed. The decoction showed antigiardial activity, reduced bacterial adherence to and invasion of HEp-2 cells and affected production of CT and action of LT. The decoction of C. rotundus does not have marked antimicrobial activity and exerts its antidiarrheal action by mechanisms other than direct killing of the pathogen.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow