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Year : 2011  |  Volume : 43  |  Issue : 2  |  Page : 200-202

Nephroprotective effect of Bauhinia variegata (linn.) whole stem extract against cisplatin-induced nephropathy in rats


1 University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar-751 004, Orissa, India
2 K. V. Virani Institute of Pharmacy and Research Centre, Badhada, Savarkundla - 364 515, Gujurat, India
3 Phytochemistry and Pharmacognosy Division, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar-751 004, Orissa, India

Correspondence Address:
Sabuj Sahoo
Phytochemistry and Pharmacognosy Division, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar-751 004, Orissa
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.77370

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The nephroprotective activity of the ethanolic extract of Bauhinia variegata (Linn.) whole stem against cisplatin-induced nephropathy was investigated by an in vivo method in rats. Acute nephrotoxicity was induced by i.p. injection of cisplatin (7 mg/kg of body weight (b.w.)). Administration of ethanol extract at dose levels of 400 and 200 mg/kg (b.w.) to cisplatin-intoxicated rats for 14 days attenuated the biochemical and histological signs of nephrotoxicity of cisplatin in a dose-dependent fashion. Ethanol extract at 400 mg/kg decreased the serum level of creatinine (0.65 ± 0.09; P<0.001) and urea (32.86 ± 5.88; P<0.001) associated with a significant increase in body weight (7.16 ± 1.10; P<0.001) and urine volume output (11.95 ± 0.79; P<0.05) as compared to the toxic control group. The ethanol extract of B. variegata at 400 mg/kg (b.w.) exhibited significant and comparable nephroprotective potential to that of the standard polyherbal drug cystone. The statistically (one-way-ANOVA followed by Tukey-Kramer multiple comparison) processed results suggested the protective action of B. variegate whole stem against cisplatin-induced nephropathy.






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