| RESEARCH ARTICLE
|Year : 2011 | Volume
| Issue : 2 | Page : 197-199
Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats
D Champatisingh1, PK Sahu2, A Pal2, GS Nanda1
1 Department of Pharmacology, University Department of Pharmaceutical Sciences, Bhubaneswar-751 004, Orissa, India
2 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar-751 003, Orissa, India
Objective : To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats.
Materials and Methods : Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were employed.
Results : M. pruriens (100 mg/kg) had significant anticataleptic and antiepileptic activity in HIC, MES, and PISE.
Conclusions : M. pruriens extract has the potential to be an anticataleptic and antiepileptic drug. Dopamine and 5-HT may have a role in such activity.
P K Sahu
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar-751 003, Orissa
Source of Support: None, Conflict of Interest: None
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