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| RESEARCH ARTICLE
|Year : 2011 | Volume
| Issue : 2 | Page : 121-125
Analgesic and anti-nociceptive activity of hydroethanolic extract of Drymaria cordata willd
Chandana Choudhury Barua1, Jayanti Datta Roy1, Bhaben Buragohain1, Acheenta Gohain Barua2, Prabodh Borah3, Mangala Lahkar4
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Assam, India
2 Department of Veterinary Public Health, College of Veterinary Science, Assam Agricultural University, Khanapara, Assam, India
3 Department of Microbiology, College of Veterinary Science, Assam Agricultural University, Khanapara, Assam, India
4 Department of Pharmacology, Guwahati Medical College, Bhangagarh, Guwahati, Assam, India
Objectives : To study the analgesic and anti-nociceptive activity of hydroethanolic extract of Drymaria cordata Willd.
Materials and Methods : Wistar rats and Swiss albino mice were used for studying analgesic and anti-nociceptive activity of Drymaria cordata hydroethanolic extract (DCHE) at doses 50, 100 and 200 mg/kg p.o. Various models viz. acetic acid induced writhing model (female mice), Eddy's hot plate (mice) and tail flick model (rat) for analgesic study and formalin-induced paw licking model (mice) were used for anti-nociceptive study.
Results : In acetic acid induced writhing model, effect of DCHE was better than the standard drug- indomethacin 10 mg/kg (p.o.). In the hot plate model, the maximum effect was observed at 60 min at a dose of 200 mg/kg p.o., which was higher than the standard drug morphine sulfate (1.5 mg/kg i.p.), whereas in the tail flick model, effect was comparable with morphine sulfate. In formalin-induced paw licking model, administration of DCHE completely abolished the early phase at 100 and 200 mg/kg p.o. and in the late phase, the effect of DCHE (200 mg/kg p.o.) was higher than indomethacin (10 mg/kg p.o.).
Conclusion : DCHE was effective in both non-narcotic and narcotic models of nociception, suggesting its possible action via peripheral and central mechanism. It also abolished the early phase in formalin-induced paw licking model, suggesting complete inactivation of C-fiber at higher dose. The activity can be attributed to the phyto-constituents viz tannins, diterpenes, triterpenes and steroids present in the DCHE extract. In conclusion, DCHE can be developed as a potent analgesic and anti-nociceptive agent in future.
Chandana Choudhury Barua
Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Assam
Source of Support: National Medicinal Plant Board, Govt. of India,
New Delh, Conflict of Interest: None
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