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 RESEARCH ARTICLE
Year : 2011  |  Volume : 43  |  Issue : 1  |  Page : 27-30

Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice


Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai - 117, Tamil Nadu, India

Correspondence Address:
A Vijayalakshmi
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai - 117, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.75662

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Objective : To study the anticonvulsant activity and neurotoxicity of ethanolic extract and ethyl acetate fraction of the rhizome of Smilax china (EESC and EAF, respectively) in mice. Materials and Methods : The anticonvulsant activities of EESC and EAF were studied against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in mice and neurotoxicity was determined using rotarod test. Results : The duration of hindleg extension in MES test was reduced significantly (P < 0.001) by EESC at a dose level of 400 mg/kg and EAF at both higher dose levels (200 and 400 mg/kg). In PTZ model, the seizure latency was prolonged by all the test groups. Conclusion : The EESC and EAF may help to control petit mal and grand mal seizures.






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