|Year : 2010 | Volume
| Issue : 6 | Page : 362-365
A comparative study on the efficacy, safety, and cost-effectiveness of bimatoprost/timolol and dorzolamide/timolol combinations in glaucoma patients
R Jothi1, AM Ismail2, R Senthamarai2, Siddhartha Pal2
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641 402, Tamilnadu, India
2 Department of Pharmacy Practice, Periyar College of Pharmaceutical Sciences for Girls, Trichirappalli-620 021, Tamilnadu, India
|Date of Submission||02-Apr-2010|
|Date of Decision||03-Jun-2010|
|Date of Acceptance||07-Aug-2010|
|Date of Web Publication||21-Oct-2010|
Department of Pharmacy Practice, Periyar College of Pharmaceutical Sciences for Girls, Trichirappalli-620 021, Tamilnadu
Source of Support: We thank Tamilnadu Pharmaceutical Welfare trust and Tamilnadu State Council for Science and Technology- Department of Biotechnology for providing the fund and support. We express our special thanks to Dr. Nalitha G. Maduram, Department of Glaucoma, Vasan eye care Hospital, Trichy. We also thank Mr.S.Wasim Raja for his support in the preparation of this manuscript, Conflict of Interest: None
Aim: This study was designed to compare the bimatoprost/timolol combination and dorzolamide/timolol combination in glaucoma for efficacy, safety, and cost-effectiveness in a local population of Trichy in the state of Tamilnadu.
Materials and Methods: Eight-week, randomized, parallel group, open-label study was conducted on 48 patients of open angle glaucoma or ocular hypertension. After initial clinical assessment and baseline investigations, bimatoprost/timolol combination (Group A) was prescribed to 22 patients (2 patients lost after initial assessment) and dorzolamide/timolol combination (Group B) to 24 patients. The patients were reviewed after second and eighth weeks for cure rate and adverse drug reaction monitoring.
Results: At the end of 8 weeks, the mean reduction in intraocular pressure from baseline was 13.04 mmHg (95% confidence interval (CI): 10.67-14.70) with bimatoprost/timolol combination once daily (P < 0.01) and 9.46 mmHg (95% CI: 7.47-10.5) with dorzolamide/timolol combination twice daily. Both the treatments were safe. Cost-effective range of bimatoprost/timolol combination was lower than that of dorzolamide/timolol combination.
Conclusion: The fixed combination of bimatoprost/timolol was slightly more effective than that of dorzolamide/timolol combination in reducing IOP, and both treatments were generally well tolerated. Bimatoprost/timolol combination was more cost-effective (cost-effective analysis) than dorzolamide/timolol combination.
Keywords: Bimatoprost/timolol, dorzolamide/timolol, intraocular pressure, ocular hypertension
|How to cite this article:|
Jothi R, Ismail A M, Senthamarai R, Pal S. A comparative study on the efficacy, safety, and cost-effectiveness of bimatoprost/timolol and dorzolamide/timolol combinations in glaucoma patients. Indian J Pharmacol 2010;42:362-5
|How to cite this URL:|
Jothi R, Ismail A M, Senthamarai R, Pal S. A comparative study on the efficacy, safety, and cost-effectiveness of bimatoprost/timolol and dorzolamide/timolol combinations in glaucoma patients. Indian J Pharmacol [serial online] 2010 [cited 2021 Dec 8];42:362-5. Available from: https://www.ijp-online.com/text.asp?2010/42/6/362/71917
| » Introduction|| |
Glaucoma affects nearly 66.7 million individual worldwide, and it is one of the leading causes of irreversible blindness. , Glaucoma is a group of ocular disorder involving optic neuropathy characterized by changes in optic nerve head and loss of visual sensitivity and field.  It is estimated that the number of patients with glaucoma will increase up to 79.6 million by the year 2020. Of these, 74% will have open angle glaucoma. From 2010 to 2020, the most detectable change in glaucoma worldwide will be an increase of the incidence of glaucoma in India. ,
Lowering the intraocular pressure (IOP) by early treatment reduces the loss of visual field in patients with glaucoma and ocular hypertension. , When a single medication does not reduce IOP significantly, a fixed combination may improve both the compliance and the quality of life.  A fixed dose combination of latanoprost and timolol was first prostaglandin analogue/beta-blocker made available in the market. Bimatoprost/timolol is a new fixed combination antiglaucoma therapy. Among the newer agents available to treat glaucoma and ocular hypertension are prostaglandin analogues, carbonic anhydrase inhibitors, and beta blockers.  Comparison studies have been done between these group of drugs. ,,,, In this study, the effect of bimatoprost/timolol has been compared with that of dorzolamide/timolol in glaucoma patients in India.
| » Materials and Methods|| |
This interventional, 8-week, randomized, open-label, parallel-group study was conducted at an eye hospital in Trichy city. The study was carried out from June to December 2008. The protocol was approved by Institutional Ethics Committee (IEC). Informed consent was obtained from patients prior to the conduct of the study.
Inclusion/exclusion criteria are mentioned below. Patients on taking ocular hypotensive medication underwent the following washout periods before inclusion: 4 days for parasympathomimetics or carbonic anhydrase inhibitors, 2 weeks for sympathomimetics or topical alpha adrenergic agonists, 4 weeks for topical alpha blockers, prostaglandin, and combination therapy.
Following patients were included in the study:
- Age: 21 years or more
- Patients with chronic open angle glaucoma, ocular hypertension, pseudoexfoliative glaucoma, and pigmentary glaucoma.
- IOP in each eye ≥22 mmHg at 8 a.m. on day 0 (after washout)
- Best corrected visual acuity 20/100 or better in each eye
Patients with anticipated alteration of ongoing therapy with agents that could interact with study medications, chronic use of ocular medication other than the study drugs, progressive or functionally significant visual field loss within the past year, pregnant or lactating females, patients with dry eyes, corneal abnormality or any other conditions that prevent related applanation tonometry, patients with ocular infection, advanced cataract, ocular inflammation or history of renal, or hepatic impairment were excluded from the study.
Study visits and treatment schedule
On the basis of the inclusion and exclusion criteria, 48 patients were selected during the study period. At baseline visit apart from the personal characteristics, IOP was measured using applanation tonometry (Gem Optical Instruments Industry, Haryana, India). The patients were randomized into two groups (according to their economic status) to receive either fixed combination of bimatoprost/timolol once a day (evening) (Group A) or dorzolamide/timolol twice a day (Group B). Initial readings were considered as baseline, first review values were taken at the end of second week and the second review values at the end of eighth week. Participants on baseline were advised to instill the medication according to the treatment regimen. The participants were recalled at second and eighth weeks for follow-up evaluation. The baseline assessment included IOP, visual acuity (decimal value), pupil size, heart rate, and blood pressure. These assessments were also done at the end of second and eighth week visits. Adverse drugs reactions (ADRs) reported by the patients were noted.
Following interventions were carried out:
- Bimatoprost/timolol solution to be applied once daily at the rate of one drop in the affected eye/eyes. Each 3 mL medication bottle containing bimatoprost 0.03% and timolol 0.5% solution was priced at Rs. 405. One drop of the solution contained 0.015 mg of bimatoprost and 0.25 mg of timolol.
- Dorzolamide/timolol solution was applied twice daily at the rate of one drop in the affected eye/eyes. Each medication bottle contained 5 mL solution of dorzolamide 2% and timolol 0.5% and was priced at Rs. 235.50. One drop of solution contained 1 mg of dorzolamide and 0.25 mg of timolol.
Main types of cost analysis include cost-of-illness analysis, cost-minimization analysis, cost-effectiveness analysis (CEA), cost-utility analysis (CUA), cost-consequence analysis, and cost-benefit analysis (CBA).
Cost-effectiveness analysis 
The cost effectiveness was calculated, and the two interventions were compared on the basis of amount needed to treat the patient. Initially for both medications, one day cost was calculated. Then, the annual cost was calculated. Annual cost was divided by minimum IOP reduction value (mmHg) and maximum IOP reduction value (mmHg) to find the cost-effective range for both combinations.
The values for visual acuity, heart rate, pupil size, systolic blood pressure, diastolic blood pressure, and IOP between treatment groups were statistically evaluated by a repeated measures analysis of variance (ANOVA). All the values at individual time point were evaluated by intragroup comparisons made between the values obtained under baseline and treatment conditions. For this purpose, Dunnett's multiple comparison test was used. Statistical significance was achieved with P ≤ 0.05. Adverse events were evaluated by Fisher Exact test.
| » Results|| |
The 8-week study was completed by 22 out of 24 (91.67%) patients in bimatoprost/timolol group, and 24 out of 24 (100%) patients in dorzolamide/timolol group. Two patients were lost to follow-up in group A. The characteristics of patients included in this study are given in [Table 1].
Efficacy and safety
The mean changes in visual acuity, heart rate, pupillary size, and systolic/diastolic blood pressure were insignificant in both groups. Gradual reduction of IOP in both the groups was seen [Table 2]. Reduction was higher with bimatoprost/timolol combination than that of dorzolamide/timolol. These reductions for both the groups are significant at both the review phases. The 95% confidence interval for both group A and group B patients were 10.45-14.91 and 7.51-10.50, respectively. Both regimens were safe and well tolerated. No serious treatment-related adverse events were reported. Most of the adverse drug reactions were ocular or periocular and mild in severity [Table 3]. Bimatoprost/timolol combination was found to be more cost-effective than dorzolamide/timolol combination [Table 4].
|Table 4: Cost-effectiveness analysis of bimatoprost/timolol and dorzolamide/timolol combinations (n = 46)|
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| » Discussion|| |
In this study, IOP level was reduced significantly with both bimatoprost/timolol as well as dorzolamide/timolol combination. However, bimatoprost/timolol combination showed greater effectiveness than that of dorzolamide/timolol. Both these combinations had no effect on heart rate, blood pressure, and pupil size. The adverse drug reactions of bimatoprost/timolol were less than the dorzolamide/timolol. Previous pharmacoeconomic studies have concluded that bimatoprost is a cost-effective drug.  However, in our study both the combinations were compared and on pharmacoeconomic analysis it was found that bimatoprost/timolol combination was more cost-effective.
| » References|| |
|1.||Dong HS, Robert MF, Wang-Pui S. Efficacy and Safety of the fixed combinations latanoprost/timolol versus dorzolamide/timolol in patients with elevated intraocular pressure. J Ophth 2004;111:276-82. |
|2.||Constance N, Richard KL. Glaucoma screening: Current trends, Economic issues, Technology and Challenges. Curr Opin Ophthalmol 2006;17:142-52. |
|3.||Joseph TD, Robert LT, Gary CY, Gary RM, Barbara GW, Michale PA. Text book of Pharmacotherapy, A Pathophysiologic approach. 5 th ed. New York: McGraw-HILL Medical Publishing Division; 2002. p. 1665-7. |
|4.||Quigley H, Broman HT. The number of People with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006;90:262-7. |
|5.||Gupta SK, Galpalli ND, Agrawal SS, Rohit S. Recent advances in Pharmacotherapy of glaucoma. Indian J Pharmacol 2008;40:197-08. [PUBMED] |
|6.||Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M, et al. Reduction of intraocular pressure and glaucoma progression: Results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 2002;120:1268-79. [PUBMED] |
|7.||Ritch R. Natural compounds: Evidence for a protective role in eye disease. Can J Ophthalmol 2007;42:425-38. [PUBMED] [FULLTEXT] |
|8.||Remo SJ, Wang-Pui S. Comparison of latanoprost with fixed -combination dorzolamide and timolol in adult patients with elevated intraocular pressure: An eighth-week, randomized, open-label, parallel-group, multi center study in Latin America. Clin Ther 2004;26:755-6. |
|9.||James DB, Louis BC, Jay K, Amy LB, Connie C, Izabella B. Bimatoprost/Timolol fixed combination: A 3 - month, double masked, randomized parellel comparison to its individual components in patients with glaucoma or ocular hypertension. J Glaucoma 2008;17:211-6. |
|10.||Martinez A, Sanchez M. Intraocular pressure lowering effect of dorzolamide/timolol fixed combination in patients with glaucoma who were unresponsive to prostaglandin analogs/prostamides. Curr Med Res Opin 2007;23:595-9. |
|11.||Orzalesi N, Rossetti L, Bottoli A, Fumagalli E, Fogagnolo P. The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension. Arch Ophthalmol 2003;121:453-7. [PUBMED] |
|12.||Cvenkle B, Stewart JA, Nelson LA, Stewart WC. Dorzolamide/tiomolol fixed combination versus Latanoprost/ tiomolol fixed combination in patients with primary open-angle glaucoma or ocular hyprtension. Curr Eye Res 2008;13:163-8. |
|13.||Ronald EP, Max F, Allision T. Pharmacoeconomic analysis of prostaglandin and prostamide therapy for patients with glaucoma or Ocular hypertension. BMC Ophthalmol 2007;7:15-20. |
|14.||Tuil E, Hommer AB, Poulsen PB, Christensen TL, Buchholz JW, Holmstrom S. The cost - effectiveness of Bimatoprost 0.03% in the treatment of glaucoma in adult patients: A European perspective. Int J Clin Pract 2005;59:1011-6. |
[Table 1], [Table 2], [Table 3], [Table 4]
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