| RESEARCH ARTICLE |
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| Year : 2010 | Volume
: 42
| Issue : 3 | Page : 185-188 |
Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats
Vivek Srivastava1, A.H.M Viswanathaswamy1, Govind Mohan2
1 Department of Pharmacology, KLE Society College of Pharmacy, Hubli, India
2 S.N. Medical College, Agra, India
Correspondence Address:
Vivek Srivastava
Department of Pharmacology, KLE Society College of Pharmacy, Hubli
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.66844
Objectives : To study the ulcer protective property of sodium cromoglycate in pylorus-ligated rats and the biochemical role in ulcer protection by various biochemical tests.
Materials and Methods : The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wistar albino rats. The antiulcer effect of sodium cromoglycate 40 mg/kg b.w., i.p., was compared with the reference drug ranitidine 27 mg/kg b.w., i.p. The ulcer index was calculated and other biochemical parameters like free acidity, total acidity, pH, mucin, pepsin and volume of gastric juice were determined.
Results : Pylorus ligation showed a significant (P < 0.01) reduction in gastric volume, free acidity, total acidity and ulcer index as compared to the control.
Conclusion : Sodium cromoglycate has activity equipotent to ranitidine.
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