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 RESEARCH ARTICLE
Year : 2009  |  Volume : 41  |  Issue : 3  |  Page : 120-124

Hepatoprotective and anti-inflammatory activities of Plantago major L.


1 Departments of Pharmacology and Toxicology, Yuzuncu Yil University, 65300 Van, Turkey
2 Department of Pharmacology, Yuzuncu Yil University, 65300 Van, Turkey
3 Department of Pathology, Yuzuncu Yil University, 65300 Van, Turkey
4 Department of Histology-Embryology, Yuzuncu Yil University, 65300 Van, Turkey

Correspondence Address:
Hanefi Ozbek
Department of Pharmacology, Yuzuncu Yil University, 65300 Van
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.55211

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Objective: The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Plantago major L. (PM). Materials and Methods: Anti-inflammatory activity: Control and reference groups were administered isotonic saline solution (ISS) and indomethacin, respectively. Plantago major groups were injected PM in doses of 5 mg/kg (PM-I), 10 mg/kg (PM-II), 20 mg/kg (PM-III) and 25 mg/kg (PM-IV). Before and three hours after the injections, the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective Activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control, CCl4 and reference groups received isotonic saline solution, CCl4 and silibinin, respectively. Plantago major groups received CCl4 (0.8 ml/kg) and PM in doses of 10, 20 and 25 mg/kg, respectively for seven days. Blood samples and liver were collected on the 8th day after the animals were killed. Results: Plantago major had an anti-inflammatory effect matching to that of control group at doses of 20 and 25 mg/kg. It was found that reduction in the inflammation was 90.01% with indomethacin, 3.10% with PM-I, 41.56% with PM-II, 45.87% with PM-III and 49.76% with PM-IV. Median effective dose (ED50) value of PM was found to be 7.507 mg/kg. Plantago major (25 mg/kg) significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the PM (25 mg/kg) and CCl4 groups. Conclusion: The results showed that PM had a considerable anti-inflammatory and hepatoprotective activities.






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