| RESEARCH PAPER
|Year : 2006 | Volume
| Issue : 5 | Page : 341-345
Effect of eugenol on animal models of nociception
R Kurian1, DK Arulmozhi2, A Veeranjaneyulu1, SL Bodhankar1
1 Department of Pharmacology, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune 411 038, India
2 Discovery Biology, Advinus Therapeutics, Bioresearch Centre, Pune 411057, Maharashtra, India
Objective: To investigate the antinociceptive potential of eugenol on different pain models in mice.
Materials and Methods : Eugenol was evaluated (1-100 mg/kg, i.p.) in various experimentally induced pain models like, formalin induced hyperalgesia, acetic acid induced abdominal constrictions, and thermal pain experiment using Eddy's hot plate.
Results : Eugenol significantly inhibited acetic acid induced abdominal constrictions, with the maximal effect (92.73% inhibition) at 100 mg/kg. In formalin induced paw licking pain model, eugenol exhibited more pronounced antinociceptive effect in the inflammatory phase than the neurogenic phase (maximal effect was 70.33% and 42.22%, respectively, at 100 mg/kg, i.p). A mild reduction in the pain response latency at 100 mg/kg, i.p. dose of eugenol was observed in the hotplate thermal pain studies in mice. In the rotarod motor coordination experiment eugenol reduced the endurance time at the dose of 100 mg/kg, i.p.
Conclusion: The data suggest that eugenol exerts antinociceptive activity in different experimental models of pain in mice.
S L Bodhankar
Department of Pharmacology, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune 411 038
Source of Support: None, Conflict of Interest: None
[FULL TEXT] [PDF]*