|Year : 2006 | Volume
| Issue : 3 | Page : 216
Exploring Indian medicinal plants for antiulcer activity
Department of Gastroenterology, Amrita Institute of Medical Sciences, Cochin - 682 026, India
Department of Gastroenterology, Amrita Institute of Medical Sciences, Cochin - 682 026
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Balakrishnan V. Exploring Indian medicinal plants for antiulcer activity. Indian J Pharmacol 2006;38:216
We read with interest the article "Exploring Indian medicinal plants for anti ulcer activity" (Indian J Pharmacol 2006; 38: 95-99). We had studied at the Medical College, Trivandrum, properties of nimbidine, the bitter amorphous, neutral powder isolated from the oil expressed from the seed kernels of Azadirachta indica (neem) in animals as well as in humans with duodenal ulcer. It reduced the incidence and severity of histamine and cysteamine induced duodenal ulcers in guinea pigs and accelerated the healing of gastric ulcers induced by acetic acid in rats and dogs. It also significantly reduced the gastric lesions produced by aspirin and indomethacin at doses of 20-40 mg/kg, p.o. At 40 and 80 mg/kg it showed remarkable protection in chemically induced duodenal lesions in rats. Nimbidine was devoid of toxicity even at a dose of 100 mg/kg orally for 12 weeks and 1 g/kg intraperitoneally in rats.
Further, in 18 patients with endoscopy proven duodenal ulcers, nimbidine was administered in capsules, 300 mg daily (60 mg thrice daily with food and 120 mg at night) for eight weeks. All the patients became symptom-free in 2 to 4 weeks and endoscopic healing of ulcer occurred in 16 (89%) of the 18 patients within 8 weeks, results comparable to that of other modern antiulcer drugs. There were no haematological, hepatic, renal, cardiac or other side effects.
It was also shown in this study that the action of nimbidine was mainly antisecretory. [Table - 1]
Reduction of the MAO (after histamine) occurred without any change in the BAO, showing thereby that the antiulcer activity of nimbidine is mainly through its antisecretory effect. Pepsin and hexosamine secretions were not suppressed by the drug.
| References|| |
|1.||Pillai NR, Sugathan D, Seshadri C, Santhakumari G. Antigastric ulcer activity of nimbidine. Indian J Med Resear 1978;68:169-75. |
|2.||Pillai NR, Santhakumari G. Effects of nimbidine on acute and chronic gastroduodenal ulcer models in experimental animals. Planta Medica 1984;50:143-6. [PUBMED] |
|3.||Balakrishnan V. The effect of neem extract (nimbidine) in peptic ulcer healing. Proceedings, 7th World Congress of Gastroenterology. Stockholm, Sweden, 1982. |
|4.||Balakrishnan V, Narendranathan M, Subair AS, Raji EJ, Pillai NR, Santhakumari G. Nimbidine in duodenal ulcer. Tropical Gastroenterology 1985;6:23-5. |
[Table - 1]