| RESEARCH PAPER
|Year : 2006 | Volume
| Issue : 2 | Page : 115-119
Antiinflammatory activity of leaf extracts of Kalanchoe crenata Andr
Theophile Dimo1, Agathe L Fotio1, TB Nguelefack2, EA Asongalem3, P Kamtchouing1
1 Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, B.P. 812 Yaounde, Cameroon
2 Department of Animal Biology, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon
3 Department of Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon
Objective: To evaluate the acute and chronic antiinflammatory properties of leaf extracts of Kalanchoe crenata in rats.
Material and methods: The methylene chloride/methanol extract of K. crenata was extracted by using hexane, methylene chloride, ethyl acetate, and n-butanol. The antiinflammatory profile of these extracts was investigated on the basis of paw edema induced by carrageenan. The n-butanol fraction (most potent) was further assessed through acute inflammatory models induced by histamine, serotonin, and formalin. The chronic antiinflammatory and the ulcerogenic activities of the n-butanol fraction were also examined.
Results: The oral administration of n-butanol fraction (600 mg/kg) caused a maximum inhibition of about 45% in paw edema induced by carrageenan. The n-butanol fraction also exhibited acute antiinflammatory activity on paw edema induced by histamine (47.51%), serotonin (54.71%), and formalin-(40.00%) . In the chronic inflammation model, this extract showed maximum inhibition of 61.26% on the ninth day of treatment. The ulcerogenic assessment showed that ulcer indices after oral treatment with n-butanol fraction were zero and 0.4±0.2, for the 300 and 600 mg/kg doses, respectively.
Conclusion: On the basis of these findings, it may be inferred that K. crenata is an antiinflammatory and antiarthritic agent that blocks histamine and serotonin pathways. The results are in agreement with the traditional use of the plant in inflammatory conditions.
Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, B.P. 812 Yaounde, Cameroon
Source of Support: None, Conflict of Interest: None
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