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 EDUCATION FORUM
Year : 2006  |  Volume : 38  |  Issue : 1  |  Page : 13-24

P-glycoprotein: Pharmacological relevance


Department of Pharmacology & Therapeutics, Govt. Medical College, Jammu 180001, India

Correspondence Address:
Vishal R Tandon
Department of Pharmacology & Therapeutics, Govt. Medical College, Jammu 180001
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.19847

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P-glycoprotein (P-gp) is a 170 kDa membrane-bound protein, an energy-dependent efflux transporter driven by ATP hydrolysis. It is responsible for multidrug resistance of many drugs. Physiologically, it is involved in limiting the harmful exposure of toxins, drugs, and xenobiotics to the body by extruding them out of cells. It is increasingly recognized to play an important modulating role in the pharmacokinetic properties of many clinically important therapeutic agents and because of its importance in pharmacokinetics, its screening has to be incorporated into the drug discovery process. The modulation of drug transporters through inhibition or induction by various drugs or herbs can lead to significant drug-drug or drug-herb interactions by affecting various pharmacokinetic parameters of the drug. In addition, genetic polymorphism of P-gp has also been reported, which may affect drug disposition, produce variable drug effects, and may change disease risk susceptibility. As drug interactions and genetic polymorphism are important factors to be considered during drug development, P-gp may have an impact on drug development in future.






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