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 RESEARCH PAPER
Year : 2005  |  Volume : 37  |  Issue : 6  |  Page : 386-389

Anticandidal activity of Azadirachta indica


Department of Microbiology,Dr. ALM Post Graduate Institute of Basic Medical Sciences,University of Madras,Taramani, Chennai-600 113, India

Correspondence Address:
T Menon
Department of Microbiology,Dr. ALM Post Graduate Institute of Basic Medical Sciences,University of Madras,Taramani, Chennai-600 113
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.19076

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OBJECTIVE: To study the antifungal activity of 10 different extracts of seed kernels of Azadirachta indica A. Juss (Meliaceae) on Candida sps. isolated from immunocompromised patients. MATERIALS AND METHODS: The extractants used were hexane, methanol, chloroform, water, petroleum ether, dichloromethane, acetone and absolute alcohol. The products of a successive extraction procedure involving hexane, chloroform and methanol were also tested for anticandidal activity. The minimum inhibitory concentration was tested by broth dilution method at concentrations ranging from 1 to 0.0625 mg/ml. RESULTS: The ethanol extract of commercial neem seed oil, ethanol extract of neem seed kernels and the hexane extract showed best results. All strains were resistant to methanol: chloroform: water extracts and chloroform extracts of the successive extraction procedure. CONCLUSION: The hexane and alcoholic extracts of neem seed seem to be promising anticandidal agents.






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