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Year : 2005  |  Volume : 37  |  Issue : 5  |  Page : 320-324

"Quick Cycle" neoadjuvant chemotherapy in squamous cell carcinoma of cervix

1 Department of Obstetrics & Gynecology, Dayanand Medical College &Hospital, Ludhiana, Punjab, India
2 Department of Obstetrics and Gynecology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India
3 Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India
4 Specialty Ranbaxy, Mumbai, Maharashtra, India

Correspondence Address:
Shalini Rajaram
B-704 Gitanjali Apartments, Vikas Marg Extension, Delhi-110 092
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.16857

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Objective: To evaluate the efficacy and safety of a 'Quick cycle' neoadjuvant chemotherapeutic regime in squamous cell carcinoma (SCC) of cervix and monitor the response to chemotherapy using Squamous Cell Carcinoma Antigen (SCC-Ag) as tumor marker. Materials and Methods: Thirty patients with SCC of cervix (Stage I-IV) entered the study to receive three courses of multiagent neoadjuvant chemotherapy (vincristine, cisplatin and bleomycin) in a weekly regime. SCC-Ag was evaluated in these patients' pre and post-chemotherapy. Results: Patients with stage IB2 had a complete response and two of seven patients with stage IIB became operable. The overall response rate was 47.8% and complete response rate was 8.7%. Decrease in tumor volume post-chemotherapy was significant (P<0.002). Toxicity including myelosuppression was minimal. A statistically significant decrease in SCC-Ag (stage II and III) was seen post-chemotherapy (P <0.04 and 0.005, respectively). Conclusion: The weekly chemotherapeutic regime was found to be safe and effective and SCC-Ag is a useful tumor marker for monitoring response to chemotherapy.


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