IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 18421 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded865    
    Comments [Add]    
    Cited by others 28    

Recommend this journal


Year : 2005  |  Volume : 37  |  Issue : 3  |  Page : 165-168

Evaluation of hepatoprotective activity of stem bark of Pterocarpus marsupium Roxb.

1 Department of Pharmacology, National College of Pharmacy, Shimoga, Karnataka, India
2 Department of PG Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta, Karnataka, India
3 Department of Botany, S. R. N. M. College of Applied Sciences, Shimoga, Karnataka, India

Correspondence Address:
V Krishna
Department of PG Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.16213

Rights and Permissions

OBJECTIVE : To evaluate the hepatoprotective activity of Pterocarpus marsupium stem bark extracts against carbon tetrachloride (CCl4)-induced hepatotoxicity. MATERIALS AND METHODS : Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of CCl4 (0.1 ml/kg/day for 10 days). Methanol and aqueous extracts of P. marsupium stem bark were administered to the experimental rats (25 mg/kg/day, p.o. for 14 days). The hepatoprotective effect of these extracts was evaluated by the assay of liver function biochemical parameters (total bilirubin, serum protein, alanine aminotransaminase, aspartate aminotransaminase, and alkaline phosphatase activities) and histopathological studies of the liver. RESULTS : In methanol extract-treated animals, the toxic effect of CCl4 was controlled significantly by restoration of the levels of serum bilirubin, protein and enzymes as compared to the normal and the standard drug silymarin-treated groups. Histology of the liver sections of the animals treated with the extracts showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration, which further evidenced the hepatoprotective activity. CONCLUSION : Methanol extract of the stem bark of P. marsupium possesses significant hepatoprotective activity.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow