| RESEARCH PAPER |
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| Year : 2005 | Volume
: 37
| Issue : 1 | Page : 33-36 |
Evaluation of CNS activity of Bramhi Ghrita
GS Achliya, SG Wadodkar, AK Dorle
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur - 440 033, India
Correspondence Address:
G S Achliya
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur - 440 033
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.13853
OBJECTIVE: To eavaluate the CNS activity of Bramhi Ghrita, a polyherbal formulation containing Bacopa monneri, Evolvulus alsinoids, Acorus calamus, Saussurea lappa and cow's ghee.
MATERIALS AND METHODS: The effect of Bramhi Ghrita on motor coordination, behavior, sleep, convulsions, locomotion and analgesia was evaluated in mice using standard procedures.
RESULTS: The formulation exhibited reduced alertness, spontaneous locomotor activity and reactivity. It also antagonized the behavioral effects of d-amphetamine, potentiated the pentobarbitone-induced sleep and increased the pain threshold. Bramhi Ghrita protected mice from maximum electroshock and pentylene tetrazole-induced convulsions.
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