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Year : 2002  |  Volume : 34  |  Issue : 5  |  Page : 350-355

Intraventricular methotrexate: motor deficit in male Wistar rats

Correspondence Address:
Madhyastha Sampath

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Source of Support: None, Conflict of Interest: None

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Objectives: The effect of BR-16A (MentatR) on aluminium-induced cognitive deficits and cognition in aged rats was studied in a one-trial step-through passive avoidance task. Methods: Aluminium chloride (1000 mg/kg/day) was administered to wistar rats for 40 days to produce significant cognitive deficits (P<0.05). Aluminium-treated rats received BR-l 6A (100 mg/kg/day) for 20 days starting day 21. In a second experiment, aged wistar rats (12 months) received BR-16A (100 mg/kg/day) or vehicle for 20 days. Results: BR-16A significantly prolonged the shortened latency of step-through induced by aluminium administration [300 (214.17 - 300) vs 60.5(16 - 213); P<0.05] It also significantly improved retention of learning in aged rats [300(120.8 - 300) vs 37(27.5 - 189.5); P<0.01]. Conclusion: These results suggest that BR-16A improves learning and memory in aluminium-treated and aged rats.


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