| SHORT COMMUNICATION
|Year : 2002 | Volume
| Issue : 5 | Page : 350-355
Intraventricular methotrexate: motor deficit in male Wistar rats
Madhyastha Sampath, SN Somayaji, K Nalini, BS Nayak, KL Bairy
Objectives: The effect of BR-16A (MentatR) on aluminium-induced cognitive deficits and cognition in aged rats was studied in a one-trial step-through passive avoidance task.
Methods: Aluminium chloride (1000 mg/kg/day) was administered to wistar rats for 40 days to produce significant cognitive deficits (P<0.05). Aluminium-treated rats received BR-l 6A (100 mg/kg/day) for 20 days starting day 21. In a second experiment, aged wistar rats (12 months) received BR-16A (100 mg/kg/day) or vehicle for 20 days.
Results: BR-16A significantly prolonged the shortened latency of step-through induced by aluminium administration [300 (214.17 - 300) vs 60.5(16 - 213); P<0.05] It also significantly improved retention of learning in aged rats [300(120.8 - 300) vs 37(27.5 - 189.5); P<0.01].
Conclusion: These results suggest that BR-16A improves learning and memory in aluminium-treated and aged rats.
Source of Support: None, Conflict of Interest: None