| RESEARCH PAPER
|Year : 2002 | Volume
| Issue : 5 | Page : 321-331
Acute toxicity studies of CC2: An effective chemical decontaminant of sulphur mustard in hydrophilic formulation
R Vijayaraghavan, Kumar Pravin, DK Dubey, Singh Ram, AS Sachan, Kumar Deo, K Sugendran, Kumar Om, Singh Maninder, SC Pant, R Bhattacharya
Cycleanine, an alkaloidal extractive from the root bark of Synclisia scabridav, was screened for some peripheral and central effects in addition to acute toxicological investigation. The intraperitoneal LD50 in mice was established as 1010.5 mg/kg. In vivo studies using mice revealed that cycleanine significantly reduced spontaneous motor activity (SMA) in a dose related manner. There was synchronization of EEG and activation of EMG. In vitro studies using isolated rat uterus showed that cycleanine evoked concentration dependent contractions that were resistant to atropine but blocked by salbutamol. These results help to explain the rationale for the folkloric use of the plant in various CNS and peripheral disorders, and also implicate cycleanine as the putative active component.
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