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 SHORT COMMUNICATION
Year : 2000  |  Volume : 32  |  Issue : 6  |  Page : 369-371

Toxicological and pharmacological study of navbal rasayan-A metal based formulation



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Chandra Dinesh


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Objectives: Toxicological and pharmacological studies of "Navbal Rasayan" a metal based Ayurvedic formulation used for the treatment of multiple sclerosis, have been carried out. Methods: Acute and chronic toxicities studies were conducted in rats with oral graded doses (0.37 to 3.0 g/kg) of Navbal Rasayan (NR). In-vitro study was carried out on isolated guinea pig ileum obtained from control or animal pretreated with oral NR, 1.5 g/kg for 3 days. Dose responses with acetylcholine, histamine and 5-HT were obtained. The analgesic activity of oral NR 1.5 g/kg for 3 days was evaluated in albino mice against acetic acid induced writhings. The hypnotic activity was measured with pentobarbital after oral pretreatment with 1.5 and 3.0 g/kg NR for 3 days. The anti-convulsant activity was observed in rats against i.p. pentylenetetrazol induced seizures. Results: Oral administration of graded doses of NR (upto 3.0 g/kg) did not produce any acute or chronic toxicities in rats. Oral pretreatment of guinea pigs with NR (1.5 g/kg for 3 days) increased 36.43 time the histamine dose while the agonistic effect of acetylcholine and 5-hydroxytryptamine was completely attenuated. Further, NR neither exhibited any analgesic, sedative effect or anticonvulsant effect in rodents. Conclusion: Toxicological and pharmacological study with NR in animals does not show any toxic effect. However, decrease or attenuation of agonistic activities of histamine, acetylcholine and serotonin needs further exploration.






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