| RESEARCH PAPER
|Year : 2000 | Volume
| Issue : 6 | Page : 357-360
Analgesic and antipyretic activities of Dalbergia sissoo leaves
SW Hajare, Chandra Suresh, SK Tandan, J Sarma, J Lal, AG Telang
Objective: To evaluate the analgesic and antipyretic activities of alcoholic extract of Dalbergia sissoo leaves.
Methods: The peripheral analgesic activity of Dalbergia sissoo leaves (SLE; 100, 300 and 1000 mg/kg) was studied using acetic acid induced writhing in mice and by Randall-Selitto assay. The central analgesic activity of SLE was studied using hot-plate method and tail clip test in mice. The antipyretic activity of SLE was studied in Brewer's yeast-induced pyrexia in rats.
Results: SLE significantly decreased the writhing movements in mice in acetic acid-induced writhing test. SLE (1000 mg/kg) significantly increased the pain threshold capacity in rats in Randall-Selitto assay and the reaction time in hot-plate test but not in tail-clip test. It also showed significant antipyretic activity in Brewer's yeast-induced pyrexia in rats throughout the observation period of 6 h.
Conclusion: SLE may have analgesic and antipyretic activities.
S W Hajare
Source of Support: None, Conflict of Interest: None