| SHORT COMMUNICATION
|Year : 2000 | Volume
| Issue : 5 | Page : 318-320
Role of nitric oxide in central regulation of humoral immune response in rats
Roy Sunita, Roy Goutam, SC Mishra, V Raviprakash
Objective: To investigate the role of nitric oxide (NO) in central regulation of immune response in rats.
Methods: The investigation was carried out using sheep red blood cells (SRBC)-immunized rats. The animals were administered NO modulators intracerebroventricularly ( icv), both prior to, and following immunization. Blood collected postimmunization was analyzed for humoral immune response by haemagglutination test.
Results: Centrally administered NO stimulators (L-arginine and SIN-1) were found to have immunopotentiating effect whereas, L- NAME (NOS inhibitor) and methylene blue (guanylyl cyclase inhibitor) did not produce any change in humoral immune response.
Conclusion: L- arginine (NO precursor) and SIN-1 (NO donor) when administered icv produced an increase in the anti-SRBC antibody titre, while L-NAME and methylene blue (NO inhibitors) did not alter this humoral immune response.
Source of Support: None, Conflict of Interest: None