| RESEARCH PAPER
|Year : 2000 | Volume
| Issue : 5 | Page : 305-308
Pharmacokinetics of enrofloxacin in febrile cross-bred bovine calves
AH Ahangar, AK Srivastava
Objective: To determine the pharmacokinetics, urinary excretion and dosage regimen of enrofloxacin in febrile cross-bred bovine calves.
Methods: Fever was induced with iv injection of E. coli endotoxin (1(g/kg). Following single iv administration of enrofloxacin (5mg/kg) in febrile calves, the blood and urine samples were collected at different predetermined time intervals. The level of drug in plasma and urine was measured by microbiological assay using Staphylococcus aureus (ATCC 6538P) as test organism. The minimum detection level of enrofloxacin was 0.02 (g/ml. The data on plasma drug concentration-time profile were analysed by nonlinear least-square regression technique.
Results: The peak plasma level of enrofloxacin at 1 min was 36.7 ( 1.15 (g/ml. The minimum therapeutic concentration was maintained up to 4 h. The t 1/2( , t 1/2(, V d(area) and ClB were 0.05 ( 0.004 h, 1.02 ( 0.05 h, 0.44 ( 0.02 L.kg and 0.30 ( 0.01 L/kg/h, respectively. Approximately 10% of total administered dose was excreted in urine within 24 h.
Conclusion: The most appropriate intravenous dosage regimen of enrofloxacin in febrile cross bred bovine calves would be 7 mg/kg repeated at 6 h intervals.
A H Ahangar
Source of Support: None, Conflict of Interest: None