| RESEARCH PAPER
|Year : 2000 | Volume
| Issue : 5 | Page : 288-293
Hepatoprotective and toxicological evaluation of Andrographis paniculata on severe liver damage
Trivedi Neha, UM Rawal
Objectives: To study the hepatoprotective effect of aqueous extract of Andrographis paniculata (AP) on hexachlorocyclohexane (BHC) induced severe liver damage in Swiss male mice.
Methods: The aqueous extract of Andrographis paniculata was given orally to the animals with liver damage induced by hexachlorocyclohexane (BHC). The hepatoprotective activity was monitored by estimating serum ALT & AST and other parameters like alkaline phosphatase, (-Glutamyl transpeptidase, glutathione and lipid peroxidase.
Results: Aqueous extract of Andrographis paniculata inhibited BHC induced liver toxicity in Swiss male mice as assessed by the biochemical values.
Conclusions: Aqueous extract of Andrographis paniculata has significant hepatoprotective activity.
Source of Support: None, Conflict of Interest: None