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Year : 2000  |  Volume : 32  |  Issue : 5  |  Page : 269-281

Pilosebaceous unit: anatomical considerations and drug delivery opportunities



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P Singh


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Pilosebaceous unit is composed of hair follicle, hair shaft and sebaceous gland. This three-dimensional complex structure present on the surface of mammalian skin has been considered as an important pathway for percutaneous absorption of topically applied drugs and delivery systems. This pathway could be exploited for localized drug delivery for diseases associated with pilosebaceous gland vis-…-vis systemic absorption of drugs. A comprehensive overview of pilosebaceous anatomy and surrounding environment is needed for rationale designing of drug delivery systems targeted toward hair follicle. The present communication presents a review of hair follicle anatomy with physiological environment, rationale, opportunities, means and modes for drug targeting to pilosebaceous compartment.






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