| SHORT COMMUNICATION
|Year : 2000 | Volume
| Issue : 3 | Page : 242-245
Effect of locomotor activity on the passive avoidance test for the evaluation of cognitive function
Vohora Divya, SN Pal, KK Pillai
Objective: To probe whether locomotor activity (LA) affects passive avoidance response (PAR) in mice
Methods: PAR and LA were studied in mice treated with known amnesic (scopolamine, diazepam) and nootropic (piracetam, Bacopa monniera extract) drugs. For PAR, the step-down latency (SDL), step-down errors (SDE) and time spent in shock zone (TSZ) were measured. A videopath analyzer was used for recording LA.
Results: An increase in LA augmented SDE scores and vice-versa, indicating a direct correlation. No such correlation was seen between LA and the other two parameters viz SDL and TSZ. The latter increased with amnesic agents and decreased in nootropic treated animals.
Conclusion: LA affects parameters for evaluation of cognitive function by the PAR test. TSZ appears to be the best indicator for nootropic/amnesic activity.
Source of Support: None, Conflict of Interest: None