IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 602 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded238    
    Comments [Add]    

Recommend this journal


Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 198-201

Protective effect of Abana ®, a poly-herbal formulation, on isoproterenol-induced myocardial infarction in rats

Correspondence Address:
Sasikumar C Sheela

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objective: To find out the possible role of lipid peroxidation and glutathione in the pathogenesis of myocardial infarction and the protective role of Abana, a polyherbal drug. Methods: The effect of Abana pretreatment (75 mg /100 g ) for a period of 60 days on isoproterenol (20 mg/100g s.c. twice at an interval of 24 hrs) induced lipid peroxidation was studied in rats. Marker enzymes levels such as creatine kinase, lactate dehydrogenase, alanine transaminase and aspartate transaminase were assessed in serum and heart homogenate. Glutathione content and lipid peroxide level were also estimated. Results: In isoproterenol administered rats, a significant decrease was observed in the levels of marker enzymes in the heart with a corresponding increase in their levels in serum. Lipid peroxide level measured in terms of "TBA reactants" increased significantly in serum and heart. In rats pretreated with Abana, the alterations observed in the marker enzymes and lipid peroxide level were minimum on isoproterenol administration, and the levels were retained at near normal values. Conclusion: Abana pretreatment may offer protection in experimental myocardial infarction induced by isoproterenol.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow