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Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 192-197

Sodium arsenite induced alteration in functional activity of murine peritoneal macrophages

Correspondence Address:
Bishayi Biswadev

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Source of Support: None, Conflict of Interest: None

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Objective: To study the effect of sodium arsenite exposure on the functions of murine leukocytes and humoral immune response. Methods: Male (BALB/c) mice were continuously exposed to sodium arsenite (NaAsO2 ) for two weeks. Fractions of peritoneal macrophages were separated and their functional activities were determined. To test the effects of arsenic on the humoral immune response heat killed S.aureus was injected and the titre of the antiserum was measured. Results: The mean phagocytic index (P.I) of control macrophage (M() is decreased from 25571.43 ( 1126.26 to 4905.30 ( 556.70 after Sodium arsenite treatment, whereas the mean P.I of S. aureus primed M( (47147.44 ( 666.36) is also decreased to 15965.91 ( 1185.95 in case of arsenite exposure followed by S.aureus immunization (P<0.001). Intracellular killing capacity in control cell is (68.4%) which is found to be 77.3% in case of NaAsO2 treatment and they can kill only 22.7% bacteria. The chemotactic index also decreases significantly in case of arsenic treated cell (2.5( 0.02) with respect to that of control cell (9.83( 0.22) at 60 min. In S.aureus immunized serum, agglutination titre was obtained at lowest antibody conc(1:512), whereas serum from pre-exposure of arsenite followed by S.aureus immunization showed early agglutination (1:32). Conclusion: Sodium arsenite exposure interferes with the immunological functions and antibody raising capacity of peritoneal macrophages in BALB/C mice.


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