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Year : 1998  |  Volume : 30  |  Issue : 5  |  Page : 334-338

Effect of serotonergic agents on amphetamine induced stereotypy

Correspondence Address:
C S Kandi

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Source of Support: None, Conflict of Interest: None

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0bjective:To study the effect of serotonergic agents on the amphetamine induced sniffing, biting, grooming and repetitive head movements. Methods:Effect of pretreatment with parachlorophenylalanine, I-tryptophan,fluoxetine, (+)fenfluramine, buspirone, cyproheptadine and ianserin on amphetamine induced sniffing and biting (in rats) and grooming and repetitive head movements (in mice) were observed. Results: Latency to sniffing and biting was decreased by parachlorophenylalanine and increased by buspirone, I-tryptophan, fenfluramine and mianserin. Latency to grooming was increased by I-tryptophan, fenfluramine and fluoxetine and decreased by cyproheptadine, parachlorophenylalanine, mianserin and buspirone.The latency to repetitive head movements was reduced by I tryptophan, fenfluramine and increased by cyproheptadine, parachlorophenylalanine, mianserin and buspirone. Conclusion: Serotonergic agents modify amphetamine induced stereotypy. The serotonergic agents produce differential effects on different components of amphetamine stereotypy


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