| RESEARCH PAPER
|Year : 1998 | Volume
| Issue : 5 | Page : 334-338
Effect of serotonergic agents on amphetamine induced stereotypy
CS Kandi, BR Metkar, VS Kasture, SB Kasture
0bjective:To study the effect of serotonergic agents on the amphetamine induced sniffing, biting, grooming and repetitive head movements.
Methods:Effect of pretreatment with parachlorophenylalanine, I-tryptophan,fluoxetine, (+)fenfluramine, buspirone, cyproheptadine and ianserin on amphetamine induced sniffing and biting (in rats) and grooming and repetitive head movements (in mice) were observed.
Results: Latency to sniffing and biting was decreased by parachlorophenylalanine and increased by buspirone, I-tryptophan, fenfluramine and mianserin. Latency to grooming was increased by I-tryptophan, fenfluramine and fluoxetine and decreased by cyproheptadine, parachlorophenylalanine, mianserin and buspirone.The latency to repetitive head movements was reduced by I tryptophan, fenfluramine and increased by cyproheptadine, parachlorophenylalanine, mianserin and buspirone.
Conclusion: Serotonergic agents modify amphetamine induced stereotypy. The serotonergic agents produce differential effects on different components of amphetamine stereotypy
C S Kandi
Source of Support: None, Conflict of Interest: None