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Year : 1998  |  Volume : 30  |  Issue : 5  |  Page : 329-333

Proconvulsant effect of buspirone and its modulation by a2-adrenoceptor agonist in mice

Correspondence Address:
Vohora Divya

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Source of Support: None, Conflict of Interest: None

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Objectives: To study (a) the effect of buspirone on chemically-induced seizures in mice and (b) the possible receptor mechanisms involved. Methods: Picrotoxin 8 mg/kg ip was used for inducing seizures in mice. The onset and duration of convulsions and recovery/ death were observed. Animals were also observed for different stages of convulsions and a severity score was assigned to them. Results: Buspirone (20 mg/kg po) potentiated PTX-induced convulsions and reversed the anticonvulsant effect of diazepam. Clonidine pretreatment protected against the pro-convulsive effects of buspirone. Mianserin exhibited an effect similar to that of buspirone. Conclusion: Buspirone exhibited pro-convulsive action on seizures induced with PTX in mice. The study suggests a role of central ((-adrenoceptor in such effects.


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