IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 2506 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded271    
    Comments [Add]    

Recommend this journal


Year : 1998  |  Volume : 30  |  Issue : 5  |  Page : 326-328

Potentiation of antiepileptic activity of phenytoin by calcium channel blockers against maximal electroshock seizure in mice

Correspondence Address:
R N Chattopadhyay

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objectives: To study the antiepileptic effect of verapamil, nifedipine and diltiazem against MES in mice. Methods: MES was induced in mice by a Techno Electroconvulsometer (50m Amp, 0.1 sec. duration). The abolition or reduction of duration of tonic extension was considered as the index for antiepileptic effect. The animals were treated with calcium channel blockers alone and in combination with phenytoin sodium. Results: Verapamil, nifedipine and diltiazem produced no significant antiepileptic effect alone. Verapamil and nifedipine potentiated the antiepileptic effect of phenytoin sodium but diltiazem exerted no such potentiating effect. Conclusion: Dose of phenytoin sodium can be reduced in epileptic patients receiving verapamil or nifedipine for some other clinical conditions.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow