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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 5  |  Page : 323-325

Antispasmodic activity of diclofenac and its combination with pitofenone and fenpiverinium on rat colon



Correspondence Address:
S K Kulkarni


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Source of Support: None, Conflict of Interest: None


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Objective: To study the antispasmodic activity of diclofenac per se and its combination with pitofenone and fenpiverinium. Method: The antispasmodic activity study was carried out against acetylcholine (10 - 640 ng ml-1)-induced concentrations on rat colon. Results: Acetylcholine (10 - 640ngml-1) induced a concentration - dependent contraction of the smooth muscle. In concentration of 9.4x1O-5 and 14.1 x10-5 mol L-1 diclofenac, a non-steroidal antiinflammatory agent shifted the concentration-response curve of acetylcholine to the right without suppressing the maximum, whereas diclofenac in higher concentration, 18.9x10-5 mol L-l induced unsurmountable blockade. Diclofenac (9.4x1O-5 mol L-1) potentiated antispasmodic activity of pitofenone (2.5x10-6 mol L-l) and fenpiverinium (2.3x10-8 mol L-l). Conclusion: The present study suggests that combination of diclofenac, pitofenone and fenpiverinium may prove to be an effective antispasmodic formulation.






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