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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 5  |  Page : 318-322

Effect of aqueous extract of Andrographis paniculata on liver tumor



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Objectives : Present investigation was designed to know whether the reported hepatoprotective activity of aqueous extract of Andrographis paniculata (AP) can be used for delaying the onset of liver cancerous changes as well as the reversibility of tumorogenic condition in Swiss in breed male mice. Methods :The aqueous extract was given orally to the animals suffering from liver damage - ultimately leading to tumour, induced by hexachloro cyclohexane (BHC). The histopathology and the various biochemical constituents were monitored. The parameters like protein and liver marker enzyme SGPT, SGOT and alkaline phosphatase were analysed at different time intervals. Results : SGPT, SGOT and alkaline phosphatase were found to be significantly high and the protein concentrations were reduced in BHC treated animals.The liver marker enzymes were found to be lowered in animals which were supplemented with the AP extract. Protein levels which were found to decrease on BHC treatment have shown an increase with AP supplementation. Conclusion :These results further confirm the hepato-protective property of AP and its probable role in delaying the hepatic turnerogenic condition.






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