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 RESEARCH PAPER
Year : 1998  |  Volume : 30  |  Issue : 5  |  Page : 306-310

Anticonvulsant effect of nalbuphine on maximal electroshock seizure in mice



Correspondence Address:
Manocha Anshu


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Objective :The study was designed to investigate the pro-or anticonvulsant action of natbuphine using maximal electroshock (MES) test. An attempt was also made to determine the possible opioid receptor mechanism involved. Method : MES seizures were induced in mice via transauricular electrodes (60mA, 0.2 sec). Seizure severity was assessed by the duration of hindlimb extensor phase. Results : lntraperitoneal administration of nalbuphine resulted in a dose-dependent inhibition of the hindlimb extensor phase during the MES. This anticonvulsant effect was antagonized by naloxone, MR2266 and naltrindole. Conclusion :The results suggest that the anti-MES effect of nalbuphine is evoked by stimulation of mu, kappa and delta receptors, since the effect was attenuated by respective receptor antagonists.






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