IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3148 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded253    
    Comments [Add]    

Recommend this journal


Year : 1998  |  Volume : 30  |  Issue : 3  |  Page : 191-194

Comparative pharmacokinetic evaluation of compressed rectal suppositories of diltiazem hydrochloride in rabbits

Correspondence Address:
Rao P Rama

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objectives: To evaluate the bioavailability of rectally administered diltiazem hydrochloride in rabbits Methods: Compressed rectal suppositories of diltiazem hydrochloride were formulated employing polyethylene glycol 4000 as base. The bioavailability of diltiazem hydrochloride from rectal suppositories was compared with that of oral administration of same dose of the drug. This study was carried out in a randomized cross over design and various pharmacokinetic parameters were calculated. Results: The maximum serum concentration (Cmax) and area under the curve (AUC0-() were significantly (p<0.05) higher in the case of rectal administration compared to oral administration. However, there was no significant difference in time for peak serum concentration (tmax) and elimination half-life (t1/2) for both rectal and oral route. Conclusions: The relative bioavailability of diltiazem hydrochloride was about 75% greater after rectal administration compared to oral route.This may be due to the avoidance of biotransformation of diltiazem by liver, intestine and lungs.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow