| RESEARCH PAPER
|Year : 1997 | Volume
| Issue : 6 | Page : 393-398
Analgesic activity of silver preparations used in Indian systems of medicine
Khanna T Ayesha, R Sivaraman, SB Vohora
Objective: To study analgesic effects and safety aspects of traditional silver preparations: Raupya Bhasma, Kushta Nuqra and Chandi Warq.
Methods: The investigations were carried out against four types of noxious stimuli: mechanical (tail clip), chemical (acetic acid-induced writhing), electrical (pododolorimeter) and thermal (Eddys hot plate and analgesiometer) in rats and mice. Effects following naloxone pre-treatment and maximum tolerated dose (MTD) were also studied.
Results: Test drugs (25-50 mg/kg, p.o) exhibited analgesic activity against chemical, thermal and electrical stimuli but not against mechanical stimulus. The effects were reduced in naloxone pre-treated animals. The MTD was more than 2 g/kg, p.o.
Conclusion: Test drugs exhibited moderate to marked analgesic effects with wide margin of safety. Involvement of opioidergic mechanism is suggested.
Khanna T Ayesha
Source of Support: None, Conflict of Interest: None