| SHORT COMMUNICATION |
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| Year : 1996 | Volume
: 28
| Issue : 4 | Page : 254-256 |
Impairment of glycerol 3-phosphate shuttle by methyl isocyanate in rats
K Jeevaratnam
Correspondence Address:
K Jeevaratnam
 Source of Support: None, Conflict of Interest: None  | Check |
The present study describes the effect of methyl isocyanate (MIC) on the hepatic glycerol 3-phosphate shuttle. Addition of MIC to the isolated rat liver mitochondria in vitro resulted in a dose-dependent inhibition of glycerol 3-phosphate dehydrogenase. Subcutaneous ad-ministration of MIC at lethal dose to rats caused a significant effect on hepatic glycerol 3- phosphate shuttle. There was a significant inhibition of both mitochondrial and cytosolic glycerol 3-phosphate dehydrogenase indicating the impairment of translocation of the reducing equivalents, NADH into the mitochondria.
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