| SHORT COMMUNICATION
|Year : 1996 | Volume
| Issue : 1 | Page : 29-31
Pro-inflammatory and pro-algesic effect of icv administered Substance P in rats
VK Dumka, SK Tandan, HC Tripathi, V Raviprakash
The central modulatory role of substance P following its icv administration (50 'g) was studied on formaldehyde-induced paw oedema and nociception in rats. A significant accentuation of oedema volume was shown along with proalgesic effect on formaldehyde-induced inflammation. A corresponding increase was also observed in protein content of the inflammatory exudate. The study confirms the pro inflammatory effect of substance P.
V K Dumka
Source of Support: None, Conflict of Interest: None