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Year : 1995  |  Volume : 27  |  Issue : 2  |  Page : 116-119

Evaluation of ocular anti-inflammatory activity of Butea frondosa

Correspondence Address:
S A Mengi

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Source of Support: None, Conflict of Interest: None

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The roots and leaves of Butea frondosa (BF) was evaluated for ocular anti-inflammatory activity in rabbits. Experimentally induced ocular inflammation manifested as rise in intraocular pressure, leucocytosis and miosis following the breakdown of blood aqueous humor barrier. The study involved the assessment of anti-inflammatory activity of BF preparations by determination of percent reduction in total leucocyte count at various time intervals. The arkas was prepared using the two parts of the plant. Commercially available eye drops of flurbiprofen and a marketed BF arka were used to compare these arkas. Statistical evaluation revealed significant difference between the aqueous preparations (P < 0.05). However, gel formulations of BF leaves arka and flurbiprofen prepared using a commercially available polymer revealed no statistically significant difference (P > 0.05). Moreover, the gels revealed the effect until 24 hours.


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