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Year : 1995  |  Volume : 27  |  Issue : 1  |  Page : 40-42

Anti-implantation activity of some H2 receptor blockers

Correspondence Address:
S S Agarwal

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Source of Support: None, Conflict of Interest: None

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Oral administration of H2-receptor blockers, cimetidine and ranitidine, to pregnant female rats daily for l-7 days post coitum exhibited anti-implantation effects. These antagonists did not possess oestrogenic/antioestrogenic activity. It appears that these compounds probably cause an inhibition of the local effect of histamine in the uterus on implantation of the fertilised ovum which may be mediated via the predominant uterine H2- receptors.


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