| SHORT COMMUNICATION
|Year : 1995 | Volume
| Issue : 1 | Page : 37-39
Preliminary studies on the anti-inflammatory effects of Swertia chirata in albino rats
Nazrul Islam Chowdhury, SK Bandyopadhyay, SN Banerjee, MK Dutta, PC Das
Aqueous suspension of total xanthones of Swertia chirata in 5% gum acacia was prepared from the aerial parts of the plant. Its anti-inflammatory effects were investigated in albino rats at a dose level of 50 mg/kg body weight (oral route) against Carrageenin, 5-HT, Dextran, Bradykinin and PGE1 induced hind paw oedema. Schirata exhibited significant antiinflam -matory activity against 5-HT and bradykinin. Mean changes in paw volume revealed the efficacy of the drug against phlogistic agents in the following order: 5-HT>Carrageenin> Bradykinin>Dextran>PGE1. Anti-inflammatory effects of Schirata was found less effective when compared with standard anti-inflammatory drugs like phenylbutazole (50 mg/kg, i.p) and betamethasone (0.5 mg/kg, i.p) in experimental models of acute and subacute inflammation.
Nazrul Islam Chowdhury
Source of Support: None, Conflict of Interest: None