IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 2520 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded149    
    Comments [Add]    
    Cited by others 6    

Recommend this journal


Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 292-295

Effect of BR-16A on alpha-2 adrenergic, dopamine autoreceptor and dopamine postsynaptic receptor functioning

Correspondence Address:
C Andrade

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

BR-16A is a herbal preparation with possible neuropsychiatric effects; preclinical work has found it to facilitate cognition and diminish both anterograde and retrograde amnesia induced by electroconvulsive shocks. The present study sought to assess whether BR-16A affects adrenergic and dopaminergic functioning in the brain. Adult, male, Sprague-Dawley rats which received BR-l 6A (200 mg/kg/day) or vehicle for one month were challenged with clonidine (100 (g/kg s.c.), apomorphine (2 mg/kg, 100 (g/kg or 50 (glkg, s.c.) or saline in separate factorial design experiments. Following the challenge, motility of the animals was assessed using a small open field. BR-l 6A did not influence hypomotility induced by clonidine agonism at alpha-2 adrenergic receptors nor by low dose apomorphine agonism at dopamine autoreceptors. However, BR 16A did augment high dose apomorphine-induced dopamine postsynaptic receptor-mediated hypermotility. These results suggest that BR-l6A does not interfere with alpha-2 adrenergic and dopamine autoreceptor functioning, and that it enhances dopamine postsynaptic receptor activity.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow