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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 225-226

Alloxan-induced diabetes in rabbits and effect of a herbal formulation D-400

Correspondence Address:
G P Dubey

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Source of Support: None, Conflict of Interest: None

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Adult male rabbits injected with alloxan (50 mg/kg, i.p.) were divided into two groups of nine each. One group received placebo and the other group an aqueous suspension of D-400, at the dose of 1gm/kg body weight orally daily for 36 weeks. Blood glucose, blood urea and serum creatinine were estimated initially and at every 6-weekly intervals. At the end of 36 weeks D-400 significantly prevented the rise in blood urea and serum creatinine levels as compared to the control. Although a rise in blood sugar was noticed in both the groups, the level of blood sugar after 36 weeks was significantly lower in the D-400 treated group. This shows the favourable response of D-400 against alloxan-induced renal damaae and hyperglycaeima.


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