IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 7905 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded116    
    Comments [Add]    
    Cited by others 4    

Recommend this journal


Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 222-224

Mechanism of hyperglycaemic effect of calcium channel antagonists in Rats

Correspondence Address:
H L Dhar

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

The mechanisms of action of calcium channel antagonists in producing hyperglycaemia was studied in rats, liyperglycaemic effect was found to be mainly due to reduced insulin release and its effect on overall glucose uptake by peripheral tissues. There was a significant fall in uptake of glucose by the diaphragm and skeletal muscle of the thigh while a rise in glycogen content in the liver. Serum insulin level was lowered significantly and the results were similar with all the three calcium channel antagonists studied. It is possible that glycogenesis in the liver limits the hypergfycaemic effect within physiological limit.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow