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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 209-212

Time dependent preventive effects of simultaneous administration of selenium or zinc during mercury exposure in rats

Correspondence Address:
GJS Flora

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Source of Support: None, Conflict of Interest: None

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Time dependent protective effects of selenium or zincsupplementation during mercury exposure was investigated in female rats. Concomitant exposure to selenium or zinc during 3 days of mercury administration prevented most of the mercury induced clinical and biochemical indices of renal toxicity. Mercury contents of kidneys were also less marked in animals administered mercury and selenium as observed on day 4. However, it increased significantly in blood while, remained unchanged in hepatic tissue. Following cessation of selenium supplementation, toxic effects of mercury reappeared on day 8. The results suggest that selenium administration reduces the renal toxicity of mercury. Zinc seems to have no preventive value against mercury.


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