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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 194-199

In vitro studies on the effect of glycyrrhizin from Indian Glycyrrhiza glabra Linn on some RNA and DNA viruses

Correspondence Address:
Badam Lalita

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Source of Support: None, Conflict of Interest: None

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Glycyrrhizin a triterpeniod glycoside obtained from Glycyrrhiza glabra Linn., was tested against some RNA (Chandipura, Measles, Polio vaccine type 1,2 and 3, Polio wild type 1,2 and 3) and DNA (Herpes type 1 and 2) viruses. It inhibited plaque formation for HSV-1 and HSV-2 at a concentration of 0.606 mM. However with Chandipura, measles and polio types 1, 2 and 3 of both the wild and the Sabin's vaccine strains, same effect could be obtained at a concentration of 1.216mM. The minimal inhibitory concentrations were not toxic to Vero (African Green Monkey kidney) and HeLa (Human Cervical carcinoma) cell lines.


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