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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 190-193

Effects of combined H1 and H2 blockers activity against histamine Induced bronchospasm in guinea pigs

Correspondence Address:
J Jena

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Source of Support: None, Conflict of Interest: None

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Both H1 and H2 blockers were studied for their protective action against histamine aerosol induced bronchospasm in guinea pigs, The H1 blockers produced significant dose dependant complete protection in some animals and significant prolongation of the exposition time in the remaining animals. Diphenhydramine was taken as the standard. The H2 blocker cimetidine also produced the same effects as the H, blockers. When both diphenhydramine and cimetidine were administered together additive effect was produced with highly significant complete protection in some animals and significant prolongation of the exposition times in the remaining animals. This suggests involvement of both H, and H2 receptors in production of histamine induced bronchospasm in guineapigs.


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