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Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 150-152

Passive cutaneous anaphylactic inhibitory and mast cell stabilizing activity of coleonol and its derivative

Correspondence Address:
P P Gupta

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Source of Support: None, Conflict of Interest: None

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Coleonol, a diterpene isolated from Coleus forskohlii which directly activates the adenylate cyclase and raises intracellular cyclic AMP levels in a variety of tissues, was studied for its effect on passive cutaneous anaphylaxis (PCA) and mast cell stabilizing activity. Coleonol has shown significant anti-PCA and mast cell stabilizing activity. However it was observed that coleonol is poorly absorbed when given orally. One of its derivative, coleonol hemisuccinate has been shown to be absorbed well when given orally.


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