| RESEARCH PAPER |
|
| Year : 1994 | Volume
: 26
| Issue : 2 | Page : 130-132 |
An Experimental and clinical evaluation of immuno-modulating potential of human placental extract
KU Ansari, Gupta Nira, SK Bapat
Correspondence Address:
K U Ansari
 Source of Support: None, Conflict of Interest: None  | Check |
Effect of human placental extract (placentrex) was investigated on immune system of rabbits as well as human volunteers. In rabbits widal agglutination test using typhoid-H antigen and DNCB & tuberculin skin sensitivity were performed as measurement of humoral and cell mediated immunity. In human volunteers humoral immunity was evaluated by immunoglobulin (IgG, IgM and IgA) estimation using tripantigen plates and the cell mediated immunity was assessed by total lymphocyte count and Tcell counts. In rabbis significant rise in H-antibody titre and increase in grades of sensitivity against DNCB and tuberculin were observed. Likewise in human subjects an increase in serum immunoglobulin as well as total lymphocyte and T-cell counts were observed. These results suggest that placentrex is immunostimulant for humoral and cell mediated immunity in animals as well as human subjects. The finding may be of immense significance for restoring dysfunction of B and T cell lymphocytes.
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