IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3427 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded112    
    Comments [Add]    

Recommend this journal


Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 121-125

The toxicity of phaseolinone to mice

Correspondence Address:
G Bhattacharya

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

The effect of phaseolinone, a phytotoxin produced by the fungus Macrophomina phaseolina, on mice was investigated. Repeated injection over a period (2 to 4 g/kg body weight divided into 45 injections) of SO days of the toxin in adult mouse induced anaemia; a significant decrease of haemoglobin content and RBC- count of blood and considerable enlargement of spleen were observed. The mitotic index of bone marrow cells was reduced. Histological study of liver and kidneys showed no change. The hematopoietic tissue region was enlarged in spleen. The 50% lethal dose (LD50) was found to be 0.98 g/kg of mouse. Infant mice were more susceptible to this toxin. Repeated injection killed a considerable percent of animals and reduced the growth rate of survivors.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow